GrippeEspagneV1, Main, Exploration, bibRecord, 000098

Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5-Year Prospective Study.

Identifieur interne : 000098 ( Main/Exploration ); précédent : 000097; suivant : 000099

Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5-Year Prospective Study.

Auteurs : M. Peghin [Espagne] ; H H Hirsch [Suisse] ; Len [Espagne] ; G. Codina [Espagne] ; C. Berastegui [Espagne] ; B. Sáez [Espagne] ; J. Solé [Espagne] ; E. Cabral [Espagne] ; A. Solé [Espagne] ; F. Zurbano [Espagne] ; F. L Pez-Medrano [Espagne] ; A. Román [Suisse, Espagne] ; J. Gavaldá [Espagne]

Source :

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2017.

RBID : pubmed:27615811

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Espagne (épidémiologie), Facteurs de risque (MeSH), Femelle (MeSH), Humains (MeSH), Infections de l'appareil respiratoire (virologie), Infections de l'appareil respiratoire (épidémiologie), Infections opportunistes (virologie), Infections opportunistes (épidémiologie), Mâle (MeSH), Pronostic (MeSH), Rejet du greffon (virologie), Rejet du greffon (épidémiologie), Transplantation pulmonaire (effets indésirables), Virus (pathogénicité), Études de suivi (MeSH), Études prospectives (MeSH).
MESH :
- effets indésirables : Transplantation pulmonaire.
- pathogénicité : Virus.
- virologie : Infections de l'appareil respiratoire, Infections opportunistes, Rejet du greffon.
- épidémiologie : Espagne, Infections de l'appareil respiratoire, Infections opportunistes, Rejet du greffon.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Mâle, Pronostic, Études de suivi, Études prospectives.

English descriptors

KwdEn :
- Female (MeSH), Follow-Up Studies (MeSH), Graft Rejection (epidemiology), Graft Rejection (virology), Humans (MeSH), Lung Transplantation (adverse effects), Male (MeSH), Middle Aged (MeSH), Opportunistic Infections (epidemiology), Opportunistic Infections (virology), Prognosis (MeSH), Prospective Studies (MeSH), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (virology), Risk Factors (MeSH), Spain (epidemiology), Viruses (pathogenicity).
MESH :
- adverse effects : Lung Transplantation.
- epidemiology : Graft Rejection, Opportunistic Infections, Respiratory Tract Infections, Spain.
- pathogenicity : Viruses.
- virology : Graft Rejection, Opportunistic Infections, Respiratory Tract Infections.
- Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors.

Abstract

The epidemiology of respiratory viruses (RVs) in lung transplant recipients (LTRs) and the relationship of RVs to lung function, acute rejection (AR) and opportunistic infections in these patients are not well known. We performed a prospective cohort study (2009-2014) by collecting nasopharyngeal swabs (NPSs) from asymptomatic LTRs during seasonal changes and from LTRs with upper respiratory tract infectious disease (URTID), lower respiratory tract infectious disease (LRTID) and AR. NPSs were analyzed by multiplex polymerase chain reaction. Overall, 1094 NPSs were collected from 98 patients with a 23.6% positivity rate and mean follow-up of 3.4 years (interquartile range 2.5-4.0 years). Approximately half of URTIDs (47 of 97, 48.5%) and tracheobronchitis cases (22 of 56, 39.3%) were caused by picornavirus, whereas pneumonia was caused mainly by paramyxovirus (four of nine, 44.4%) and influenza (two of nine, 22.2%). In LTRs with LRTID, lung function changed significantly at 1 mo (p = 0.03) and 3 mo (p = 0.04). In a nested case-control analysis, AR was associated with RVs (hazard ratio [HR] 6.54), Pseudomonas aeruginosa was associated with LRTID (HR 8.54), and cytomegalovirus (CMV) replication or disease was associated with URTID (HR 2.53) in the previous 3 mo. There was no association between RVs and Aspergillus spp. colonization or infection (HR 0.71). In conclusion, we documented a high incidence of RV infections in LTRs. LRTID produced significant lung function abnormalities. Associations were observed between AR and RVs, between P. aeruginosa colonization or infection and LRTID, and between CMV replication or disease and URTID.

DOI: 10.1111/ajt.14042
PubMed: 27615811
PubMed Central: PMC7159570

Affiliations:

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Le document en format XML

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<author><name sortKey="Zurbano, F" sort="Zurbano, F" uniqKey="Zurbano F" first="F" last="Zurbano">F. Zurbano</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5-Year Prospective Study.</title>
<author><name sortKey="Peghin, M" sort="Peghin, M" uniqKey="Peghin M" first="M" last="Peghin">M. Peghin</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Infectious Diseases, Hospital Universitari de la Vall d'Hebron, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish Network for Research in Infectious Diseases (REIPI), Seville</wicri:regionArea>
<wicri:noRegion>Seville</wicri:noRegion>
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<author><name sortKey="Hirsch, H H" sort="Hirsch, H H" uniqKey="Hirsch H" first="H H" last="Hirsch">H H Hirsch</name>
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<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Transplantation & Clinical Virology, Department Biomedicine (Haus Petersplatz), University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>Division Infection Diagnostics, Department Biomedicine (Haus Petersplatz), University of Basel, Basel, Switzerland.</nlm:affiliation>
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<wicri:noRegion>Basel</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation>
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<author><name sortKey="Len, " sort="Len, " uniqKey="Len " first="" last="Len"> Len</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish Network for Research in Infectious Diseases (REIPI), Seville</wicri:regionArea>
<wicri:noRegion>Seville</wicri:noRegion>
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<author><name sortKey="Codina, G" sort="Codina, G" uniqKey="Codina G" first="G" last="Codina">G. Codina</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish Network for Research in Infectious Diseases (REIPI), Seville</wicri:regionArea>
<wicri:noRegion>Seville</wicri:noRegion>
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<affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Microbiology, Hospital Universitari de la Vall d'Hebron, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
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<author><name sortKey="Berastegui, C" sort="Berastegui, C" uniqKey="Berastegui C" first="C" last="Berastegui">C. Berastegui</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid</wicri:regionArea>
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<author><name sortKey="Saez, B" sort="Saez, B" uniqKey="Saez B" first="B" last="Sáez">B. Sáez</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pulmonology and Lung Transplant Unit, Hospital Universitari de la Vall d'Hebron, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
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<affiliation wicri:level="3"><nlm:affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sole, J" sort="Sole, J" uniqKey="Sole J" first="J" last="Solé">J. Solé</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Thoracic Surgery, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Thoracic Surgery, Hospital Universitari de la Vall d'Hebron, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cabral, E" sort="Cabral, E" uniqKey="Cabral E" first="E" last="Cabral">E. Cabral</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Infectious Diseases, Hospital Universitari de la Vall d'Hebron, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sole, A" sort="Sole, A" uniqKey="Sole A" first="A" last="Solé">A. Solé</name>
<affiliation wicri:level="1"><nlm:affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish Network for Research in Infectious Diseases (REIPI), Seville</wicri:regionArea>
<wicri:noRegion>Seville</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Lung Transplant Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Lung Transplant Unit, Hospital Universitario y Politécnico La Fe, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zurbano, F" sort="Zurbano, F" uniqKey="Zurbano F" first="F" last="Zurbano">F. Zurbano</name>
<affiliation wicri:level="1"><nlm:affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish Network for Research in Infectious Diseases (REIPI), Seville</wicri:regionArea>
<wicri:noRegion>Seville</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Division of Pneumology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Division of Pneumology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander</wicri:regionArea>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="L Pez Medrano, F" sort="L Pez Medrano, F" uniqKey="L Pez Medrano F" first="F" last="L Pez-Medrano">F. L Pez-Medrano</name>
<affiliation wicri:level="1"><nlm:affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish Network for Research in Infectious Diseases (REIPI), Seville</wicri:regionArea>
<wicri:noRegion>Seville</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Infectious Diseases, Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roman, A" sort="Roman, A" uniqKey="Roman A" first="A" last="Román">A. Román</name>
<affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gavalda, J" sort="Gavalda, J" uniqKey="Gavalda J" first="J" last="Gavaldá">J. Gavaldá</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Infectious Diseases, Hospital Universitari de la Vall d'Hebron, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish Network for Research in Infectious Diseases (REIPI), Seville</wicri:regionArea>
<wicri:noRegion>Seville</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title>
<idno type="eISSN">1600-6143</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female (MeSH)</term>
<term>Follow-Up Studies (MeSH)</term>
<term>Graft Rejection (epidemiology)</term>
<term>Graft Rejection (virology)</term>
<term>Humans (MeSH)</term>
<term>Lung Transplantation (adverse effects)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Opportunistic Infections (epidemiology)</term>
<term>Opportunistic Infections (virology)</term>
<term>Prognosis (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Respiratory Tract Infections (epidemiology)</term>
<term>Respiratory Tract Infections (virology)</term>
<term>Risk Factors (MeSH)</term>
<term>Spain (epidemiology)</term>
<term>Viruses (pathogenicity)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections de l'appareil respiratoire (virologie)</term>
<term>Infections de l'appareil respiratoire (épidémiologie)</term>
<term>Infections opportunistes (virologie)</term>
<term>Infections opportunistes (épidémiologie)</term>
<term>Mâle (MeSH)</term>
<term>Pronostic (MeSH)</term>
<term>Rejet du greffon (virologie)</term>
<term>Rejet du greffon (épidémiologie)</term>
<term>Transplantation pulmonaire (effets indésirables)</term>
<term>Virus (pathogénicité)</term>
<term>Études de suivi (MeSH)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lung Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Transplantation pulmonaire</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Graft Rejection</term>
<term>Opportunistic Infections</term>
<term>Respiratory Tract Infections</term>
<term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term>
<term>Infections opportunistes</term>
<term>Rejet du greffon</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Graft Rejection</term>
<term>Opportunistic Infections</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term>
<term>Infections de l'appareil respiratoire</term>
<term>Infections opportunistes</term>
<term>Rejet du greffon</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The epidemiology of respiratory viruses (RVs) in lung transplant recipients (LTRs) and the relationship of RVs to lung function, acute rejection (AR) and opportunistic infections in these patients are not well known. We performed a prospective cohort study (2009-2014) by collecting nasopharyngeal swabs (NPSs) from asymptomatic LTRs during seasonal changes and from LTRs with upper respiratory tract infectious disease (URTID), lower respiratory tract infectious disease (LRTID) and AR. NPSs were analyzed by multiplex polymerase chain reaction. Overall, 1094 NPSs were collected from 98 patients with a 23.6% positivity rate and mean follow-up of 3.4 years (interquartile range 2.5-4.0 years). Approximately half of URTIDs (47 of 97, 48.5%) and tracheobronchitis cases (22 of 56, 39.3%) were caused by picornavirus, whereas pneumonia was caused mainly by paramyxovirus (four of nine, 44.4%) and influenza (two of nine, 22.2%). In LTRs with LRTID, lung function changed significantly at 1 mo (p = 0.03) and 3 mo (p = 0.04). In a nested case-control analysis, AR was associated with RVs (hazard ratio [HR] 6.54), Pseudomonas aeruginosa was associated with LRTID (HR 8.54), and cytomegalovirus (CMV) replication or disease was associated with URTID (HR 2.53) in the previous 3 mo. There was no association between RVs and Aspergillus spp. colonization or infection (HR 0.71). In conclusion, we documented a high incidence of RV infections in LTRs. LRTID produced significant lung function abnormalities. Associations were observed between AR and RVs, between P. aeruginosa colonization or infection and LRTID, and between CMV replication or disease and URTID.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27615811</PMID>
<DateCompleted><Year>2018</Year>
<Month>03</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>5</Issue>
<PubDate><Year>2017</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title>
<ISOAbbreviation>Am. J. Transplant.</ISOAbbreviation>
</Journal>
<ArticleTitle>Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5-Year Prospective Study.</ArticleTitle>
<Pagination><MedlinePgn>1304-1312</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.14042</ELocationID>
<Abstract><AbstractText>The epidemiology of respiratory viruses (RVs) in lung transplant recipients (LTRs) and the relationship of RVs to lung function, acute rejection (AR) and opportunistic infections in these patients are not well known. We performed a prospective cohort study (2009-2014) by collecting nasopharyngeal swabs (NPSs) from asymptomatic LTRs during seasonal changes and from LTRs with upper respiratory tract infectious disease (URTID), lower respiratory tract infectious disease (LRTID) and AR. NPSs were analyzed by multiplex polymerase chain reaction. Overall, 1094 NPSs were collected from 98 patients with a 23.6% positivity rate and mean follow-up of 3.4 years (interquartile range 2.5-4.0 years). Approximately half of URTIDs (47 of 97, 48.5%) and tracheobronchitis cases (22 of 56, 39.3%) were caused by picornavirus, whereas pneumonia was caused mainly by paramyxovirus (four of nine, 44.4%) and influenza (two of nine, 22.2%). In LTRs with LRTID, lung function changed significantly at 1 mo (p = 0.03) and 3 mo (p = 0.04). In a nested case-control analysis, AR was associated with RVs (hazard ratio [HR] 6.54), Pseudomonas aeruginosa was associated with LRTID (HR 8.54), and cytomegalovirus (CMV) replication or disease was associated with URTID (HR 2.53) in the previous 3 mo. There was no association between RVs and Aspergillus spp. colonization or infection (HR 0.71). In conclusion, we documented a high incidence of RV infections in LTRs. LRTID produced significant lung function abnormalities. Associations were observed between AR and RVs, between P. aeruginosa colonization or infection and LRTID, and between CMV replication or disease and URTID.</AbstractText>
<CopyrightInformation>© Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Peghin</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hirsch</LastName>
<ForeName>H H</ForeName>
<Initials>HH</Initials>
<AffiliationInfo><Affiliation>Transplantation & Clinical Virology, Department Biomedicine (Haus Petersplatz), University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division Infection Diagnostics, Department Biomedicine (Haus Petersplatz), University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Len</LastName>
<ForeName>Ó</ForeName>
<Initials>Ó</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Codina</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Berastegui</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonology and Lung Transplant Unit, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sáez</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonology and Lung Transplant Unit, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Solé</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Thoracic Surgery, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cabral</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Solé</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Lung Transplant Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zurbano</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Pneumology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>López-Medrano</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Hospital Universitario 12 de Octubre, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Román</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gavaldá</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Hospital Universitari de la Vall d'Hebron, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>10</Month>
<Day>14</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Am J Transplant</MedlineTA>
<NlmUniqueID>100968638</NlmUniqueID>
<ISSNLinking>1600-6135</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006084" MajorTopicYN="N">Graft Rejection</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016040" MajorTopicYN="N">Lung Transplantation</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009894" MajorTopicYN="N">Opportunistic Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014780" MajorTopicYN="N">Viruses</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">clinical research/practice</Keyword>
<Keyword MajorTopicYN="N">complication: infectious</Keyword>
<Keyword MajorTopicYN="N">infection and infectious agents</Keyword>
<Keyword MajorTopicYN="N">infectious disease</Keyword>
<Keyword MajorTopicYN="N">lung disease: infectious</Keyword>
<Keyword MajorTopicYN="N">lung transplantation/pulmonology</Keyword>
<Keyword MajorTopicYN="N">rejection: acute</Keyword>
<Keyword MajorTopicYN="N">viral</Keyword>
<Keyword MajorTopicYN="N">viral: influenza</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>05</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>08</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>09</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>9</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>3</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>9</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
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<ArticleId IdType="doi">10.1111/ajt.14042</ArticleId>
<ArticleId IdType="pmc">PMC7159570</ArticleId>
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Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5-Year Prospective Study.

Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5-Year Prospective Study.

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